POEMS syndrome

Definition

POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels.

Also known as Crow-Fukase syndrome, osteosclerotic myeloma, PEP syndrome, POEMS syndrome, polyneuropathy-endocrinopathy-plasma cell dyscrasia syndrome, Takatsuki syndrome — per MONDO

Also identified as

• DOID 14039 per MONDO
• MESH D016878 per MONDO
• NCIT C80303 per MONDO
• Orphanet 2905 per MONDO
• SCTID 79268002 per MONDO
• UMLS C0085404 per MONDO

Affected Organs