T-cell/histiocyte rich large B cell lymphoma

Definition

T-cell/histiocyte rich large B cell lymphoma (THRLBCL) is a rare variant of diffuse large B-cell lymphoma (DLBCL), mainly affecting middle-aged men and often not being discovered until an advanced disease stage, with involvement of the spleen, liver and bone marrow occurring at a greater frequency than in DLBCL. It is often difficult to diagnose due to its similarity with other lymphoid diseases such as classic Hodgkin lymphoma and nodular lymphocyte-predominant Hodgkin lymphoma and has an aggressive clinical course.

Also known as T-cell rich/histiocyte-rich large B-cell lymphoma, T-cell/histiocyte rich lymphoma, T-cell/histiocyte-rich large B-cell lymphoma, THRLBCL — per MONDO

Also identified as

• NCIT C9496 per MONDO
• Orphanet 300857 per MONDO
• UMLS C1321547 per MONDO

Affected Organs