Marginal zone lymphoma

Definition

A usually indolent mature B-cell lymphoma, arising from the marginal zone of lymphoid tissues. It is characterized by the presence of small to medium sized atypical lymphocytes. It comprises three entities, according to the anatomic sites involved: extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue, which affects extranodal sites (most often stomach, lung, skin, and ocular adnexa); nodal marginal zone B-cell lymphoma, which affects lymph nodes without evidence of extranodal disease; and splenic marginal zone B-cell lymphoma, which affects the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood.

Also known as lymphoma of marginal zone B cell, marginal zone B cell lymphoma, marginal zone B-cell lymphoma, marginal zone lymphoma, MZBCL, MZL — per MONDO

Also identified as

• DOID 0050748 per MONDO
• NCIT C4341 per MONDO
• Orphanet 300912 per MONDO
• SCTID 447100004 per MONDO
• UMLS C1367654 per MONDO

Affected Organs