MIT family translocation renal cell carcinoma

MIT family translocation renal cell carcinoma

Definition

MiT family translocation renal cell carcinoma (t-RCC) is a rare subtype of renal cell carcinoma with recurrent genetic abnormalities, harboring rearrangements of the TFE3 (Xp11 t-RCC) or TFEB [t(6;11) t-RCC] genes. The t(6;11) t-RCC has distinctive histologic features of biphasic appearance with larger epitheloid and smaller eosinophilic cells. The symptoms are usually non-specific and include hematuria, flank pain, palpable abdominal mass and/or systemic symptoms of anemia, fatigue and fever.

Also known as carcinoma associated with MITF/TFE translocation, translocation renal cell carcinoma — per MONDO

Also identified as

Affected Organs

Organ Involvement Source
Adult mammalian kidney Disease Has Associated Anatomic Site NCIT · CC BY 4.0
Adult mammalian kidney Disease Has Primary Anatomic Site NCIT · CC BY 4.0
Genitourinary system Disease Has Associated Anatomic Site NCIT · CC BY 4.0
Genitourinary system Disease Has Primary Anatomic Site NCIT · CC BY 4.0
Nephron tubule Disease Has Primary Anatomic Site NCIT · CC BY 4.0
Renal system Disease Has Associated Anatomic Site NCIT · CC BY 4.0
Renal system Disease Has Primary Anatomic Site NCIT · CC BY 4.0
Upper urinary tract Disease Has Associated Anatomic Site NCIT · CC BY 4.0