Oral submucous fibrosis

Definition

Oral submucous fibrosis (OSMF) is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in India and Southeast Asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro-pharynx (leading to trismus and a progressive reduction in mouth opening) and an increased risk of developing oral squamous cell cancer (3-19%). It is usually associated with the chewing of the areca nut (an ingredient in betel quid) but the exact etiology is unknown and there is currently no effective treatment.

Also known as oral cavity submucous fibrosis, oral submucosal fibrosis, including of tongue, OSMF — per MONDO

Also identified as

• DOID 5773 per MONDO
• ICD10CM K13.5 per MONDO
• ICD9 528.8 per MONDO
• MESH D009914 per MONDO
• NCIT C34866 per MONDO
• Orphanet 357154 per MONDO
• SCTID 32883009 per MONDO
• UMLS C0029172 per MONDO

Affected Organs