Acute myeloid leukemia with t(8;16)(p11;p13) translocation
Acute myeloid leukemia with t(8;16)(p11;p13) translocation
Definition
A distinct form of Acute myeloid leukemia (AML) in which this chromosomal anomaly is found de novo or in therapy-related AML cases, and is characterized by frequent extramedullary involvement (mainly hepatomegaly, splenomegaly, lymphadenopathies, cutaneous infiltration, but also gum, bone, central nervous system, testicles involvement), severe coagulation disorder (disseminated intravascular coagulopathy or primary fibrinolysis) and poor prognosis. Morphologically, a blast population with a myelomonocytic stage of differentiation is observed.
Also known as AML with t(8;16)(p11;p13) translocation — per MONDO
Also identified as
- DOID 0070630 per MONDO
- NCIT C200421 per MONDO
- Orphanet 370026 per MONDO
- SCTID 725390002 per MONDO
- UMLS C4511003 per MONDO
Affected Organs
| Organ | Involvement | Source |
|---|---|---|
| Bone marrow | Disease Has Associated Anatomic Site | NCIT · CC BY 4.0 |
| Bone marrow | Disease Has Primary Anatomic Site | NCIT · CC BY 4.0 |