Acute megakaryoblastic leukemia

Definition

Acute megakaryoblastic leukemia (AMKL) is a form of acute myeloid leukemia (AML) that occurs predominantly in childhood and particularly in children with Down syndrome (DS-AMKL). Nonspecific symptoms may be irritability, weakness, and dizziness while specific symptoms include pallor, fever, mucocutaneous bleeding, hepatosplenomegaly, neurological manifestations and rarely lymphadenopathy. Acute panmyelosis with myelofibrosis may also be associated with AMKL. In contrast to DS-AMKL (around 80 % survival), non-DS-AMKL is an AML subgroup associated with poor prognosis.

Also known as acute M7 myeloid leukaemia, acute M7 myeloid leukemia, acute megakaryoblastic leukaemia (FAB type M7), acute megakaryoblastic leukemia, acute megakaryoblastic leukemia (FAB type M7), acute megakaryoblastic leukemia, FAB M7, acute megakaryocytic leukaemia, acute megakaryocytic leukemia, acute megakaryocytic leukemias, acute myeloid leukaemia M7, acute myeloid leukemia M7, AMKL, AML M7, FAB M7, leukemia, megakaryocytic, malignant, thrombocytic leukemia — per MONDO

Also identified as

• DOID 8761 per MONDO
• ICD10CM C94.2 per MONDO
• ICD9 207.2 per MONDO
• MESH D007947 per MONDO
• NCIT C3170 per MONDO
• Orphanet 518 per MONDO
• SCTID 277602003 per MONDO
• UMLS C0023462 per MONDO

Affected Organs