Myelodysplastic syndrome

Definition

A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001)

Also known as dysmyelopoietic syndrome, hematopoeitic - myelodysplastic syndrome (MDS), MDS, MDS-U, MDS, unclassifiable, myelodysplasia, myelodysplastic neoplasm, myelodysplastic syndrome, myelodysplastic syndrome, somatic, myelodysplastic syndrome, unclassifiable, myelodysplastic syndrome/neoplasm, Myelodysplastic Syndromes, oligoblastic leukaemia, oligoblastic leukemia, preleukemia, smoldering leukemia, smouldering leukaemia — per MONDO

Also identified as

• DOID 0050908 per MONDO
• ICD10CM D46 per MONDO
• ICD9 238.7 per MONDO
• ICD9 238.75 per MONDO
• NCIT C3247 per MONDO
• OMIM 614286 per MONDO
• Orphanet 52688 per MONDO
• SCTID 109995007 per MONDO
• UMLS C3463824 per MONDO

Affected Organs