Obesity due to melanocortin 4 receptor deficiency
Obesity due to melanocortin 4 receptor deficiency
Definition
Melanocortin 4 receptor (MC4R) deficiency is the commonest form of monogenic obesity identified so far. MC4R deficiency is characterized by severe obesity, an increase in lean body mass and bone mineral density, increased linear growth in early childhood, hyperphagia beginning in the first year of life and severe hyperinsulinaemia, in the presence of preserved reproductive function.
Also known as MC4R deficiency — per MONDO