Isaac syndrome

Isaac syndrome

Definition

Isaac's syndrome is an immune-mediated peripheral motor neuron disorder characterized by continuous muscle fiber activity at rest resulting in muscle stiffness, cramps, myokymia, and pseudomyotonia.

Also known as acquired neuromyotonia, continuous muscle fiber activity syndrome, continuous muscle fibre activity syndrome, Isaacs' syndrome, neuromyotonia, peripheral nerve hyperexcitability, Quantal squander syndrome — per MONDO

Also identified as