AL amyloidosis

Definition

AL Amyloidosis is a plasma cell disorder characterized by the aggregation and deposition of insoluble amyloid fibrils derived from misfolding of monoclonal immunoglobulin light chains usually produced by a plasma cell tumor. It usually presents as primary systemic amyloidosis (PSA) with multiple organ involvement and less frequently as primary localized amyloidosis (PLA) restricted to a single organ.

Also known as Light-chain amyloidosis, primary amyloidosis — per MONDO

Also identified as

• DOID 0080933 per MONDO
• MESH C531616 per MONDO
• NCIT C158963 per MONDO
• Orphanet 85443 per MONDO
• UMLS C0268381 per MONDO

Affected Organs