Splenic marginal zone lymphoma

Splenic marginal zone lymphoma

Definition

Splenic marginal zone lymphoma is a rare, indolent B-cell non-Hodgkin lymphoma characterized by abnormal clonal proliferation of mature B-lymphocytes with involvement in the spleen, bone marrow and, frequently, the blood. It usually presents with splenomegaly, lymphocytosis, anemia and/or thrombocytopenia. Hepatitis C virus and autoimmune manifestations, such as autoimmune hemolytic anemia and autoimmune thrombocytopenia, could be associated.

Also known as marginal zone lymphoma of spleen, marginal zone lymphoma of the spleen, SLVL, SMZL, splenic lymphoma with circulating villous lymphocytes, splenic marginal zone B-cell lymphoma, splenic marginal zone B-cell lymphoma with villous lymphocytes, splenic marginal zone lymphoma, splenic marginal zone lymphoma with villous lymphocytes — per MONDO

Also identified as

Affected Organs

Organ Involvement Source
Lymphoid system Disease Has Primary Anatomic Site NCIT · CC BY 4.0
Spleen Disease Has Associated Anatomic Site NCIT · CC BY 4.0
Spleen Disease Has Primary Anatomic Site NCIT · CC BY 4.0