CD4+/CD56+ hematodermic neoplasm

ICD-10 Code C86.4

CD4+/CD56+ hematodermic neoplasm

Definition

An aggressive immature hematologic neoplasm formerly known as blastic NK cell lymphoma, composed of cells with a lymphoblast-like morphology. Recent evidence suggests derivation from a plasmacytoid monocyte. Patients present with cutaneous tumors and bone marrow involvement.

Also known as agranular CD4+ CD56+ hematodermic neoplasm/tumor, agranular CD4+ natural Killer cell leukaemia, agranular CD4+ natural Killer cell leukemia, blastic natural Killer leukemia/lymphoma, blastic NK-cell lymphoma, blastic plasmacytoid Dendritic cell neoplasm, BPDCN, CD4+/CD56+ hematodermic neoplasm, early plasmacytoid Dendritic cell leukemia/lymphoma, lymphoblastoid variant of NK-cell lymphoma, monomorphic NK-cell lymphoma, primary cutaneous CD4+/CD56+ hematolymphoid neoplasm — per MONDO

Also identified as