Methotrexate-associated lymphoproliferative disorders

Definition

Methotrexate-associated lymphoproliferative disorders are rare immunodeficiency-associated lymphoproliferative diseases characterized by lymphoid proliferation or lymphomas (large B-cell lymphoma, T-cell lymphoma, Hodgkin lymphoma, reactive lymphadenitis and a polymorphic post-transplant lymphoproliferative disorder) that develop in patients with different autoimmune diseases treated with methotrexate. Swelling is the predominant manifestation of the disease and regression after methotrexate withdrawal is observed in a significant proportion of patients.

Also known as methotrexate-associated lymphoproliferation, methotrexate-associated lymphoproliferative disorder, MTX-associated lymphoproliferative disorders, MTX-LPD — per MONDO

Also identified as

• DOID 5821 per MONDO
• NCIT C7184 per MONDO
• Orphanet 86904 per MONDO
• UMLS C1334749 per MONDO

Affected Organs