Paroxysmal cold hemoglobinuria
Paroxysmal cold hemoglobinuria
Definition
Paroxysmal cold hemoglobinuria (PCH) is a very rare subtype of autoimmune hemolytic anemia (AIHA), caused by the presence of cold-reacting autoantibodies in the blood and characterized by the sudden presence of hemoglobinuria, typically after exposure to cold temperatures.
Also known as Donath-Landsteiner hemolytic anaemia, Donath-Landsteiner hemolytic anemia, Donath-Landsteiner syndrome, PCH — per MONDO