Tenosynovial giant cell tumor, diffuse type
Tenosynovial giant cell tumor, diffuse type
Definition
A locally aggressive, diffusely infiltrating tumor, arising in the tendon sheath. It is composed of synovial-like mononuclear cells, hemosiderin-laden macrophages, foam cells, and inflammatory cells. Multinucleated osteoclast-like giant cells are usually present, although in a minority of cases they may be absent or rare. It predominantly affects young adults. Symptoms include joint swelling, pain, and joint effusion.
Also known as diffuse giant cell neoplasm of tendon sheath, diffuse giant cell neoplasm of Tenosynovium, diffuse giant cell neoplasm of the Tenosynovium, diffuse giant cell tumor of tendon sheath, diffuse giant cell tumor of Tenosynovium, diffuse giant cell tumor of the Tenosynovium, diffuse giant cell tumour of tendon sheath, diffuse giant cell tumour of Tenosynovium, diffuse giant cell tumour of the Tenosynovium, diffuse tenosynovial giant cell neoplasm, diffuse tenosynovial giant cell tumor, diffuse tenosynovial giant cell tumour, pigmented villonodular synovitis, tenosynovial giant cell tumor, diffuse type, TGCT, TSGCT — per MONDO