Nodular lymphocyte predominant Hodgkin lymphoma

Definition

A monoclonal B-cell neoplasm characterized by a nodular, or a nodular and diffuse proliferation of scattered large neoplastic cells known as popcorn or lymphocyte predominant cells (LP cells)- formerly called L&H cells for lymphocytic and/or histiocytic Reed-Sternberg cell variants. The LP cells lack CD15 and CD30 in nearly all instances. Patients are predominantly male, frequently in the 30-50 year age group. Most patients present with limited stage disease (localized peripheral lymphadenopathy, stage I or II). (WHO 2008)

Also known as Hodgkin lymphoma nodular LP, NOS, Hodgkin lymphoma nodular lymphocyte predominant type, NOS, NLPHL, nodular lymphocyte predominant Hodgkin lymphoma, nodular lymphocyte predominant Hodgkin's lymphoma, nodular lymphocyte-predominant Hodgkin lymphoma — per MONDO

Also identified as

• ICD10CM C81.0 per MONDO
• NCIT C7258 per MONDO
• Orphanet 86893 per MONDO
• UMLS C1334968 per MONDO

Affected Organs