BN2 diffuse large B-cell lymphoma

Definition

A diffuse large B-cell lymphoma that is categorized as BN2 with high probability by the LymphGen algorithm. This is based on a combination of genetic features and BN2 DLBCLs often, but do not always, have a translocation involving the BCL6 locus and/or some combination of mutations affecting NOTCH2, TNFAIP3, BCL10 and UBE2A. This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting CD70, which can be coding or non-coding.

Also identified as

• DOID 0081064 per MONDO
• NCIT C148395 per MONDO
• UMLS C4725003 per MONDO

Affected Organs