MCD diffuse large B-cell lymphoma

Definition

A diffuse large B-cell lymphoma that is categorized as MCD with high probability by the LymphGen algorithm. This is based on a combination of genetic features and MCD DLBCLs often, but do not always, have the most common hot spot mutation in MYD88 (L265P) and/or activating mutations in CD79B. This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting PIM1 and/or ETV6, which can be coding or non-coding.

Also identified as

• DOID 0081066 per MONDO
• NCIT C148394 per MONDO
• UMLS C4725002 per MONDO

Affected Organs