Neurodevelopmental disorder with cerebellar atrophy and motor dysfunction

Neurodevelopmental disorder with cerebellar atrophy and motor dysfunction

Definition

A neurodevelopmental disorder caused by variation in the GEMIN5 gene, characterized by global developmental delay with prominent motor abnormalities, mainly axial hypotonia, gait ataxia, and appendicular spasticity.

Also known as GEMIN5 disorder, GEMIN5-related neurodevelopmental disorder, NEDCAM — per MONDO

Also identified as