Anti-MDA5 dermatomyositis

Definition

A dermatomyositis characterized by the presence of anti-MDA5 autoantibodies. It is often associated with dermatomyositis rashes, amyopathic or hypomyopathic muscle involvement and interstitial lung disease, frequently as a rapid progressive course and high mortality.

Also known as anti-melanoma differentiation-associated gene 5 dermatomyositis, MDA-5 DM, MDA5+ DM — per MONDO