Melanotic neurilemmoma

Definition

A rare circumscribed, non-encapsulated and grossly pigmented nerve sheath tumor. It is composed of cells with the immunophenotypic and electron microscopic features of Schwann cells which contain melanosomes and are positive for melanoma markers. It usually involves spinal nerve roots but may occur in other locations. It may be associated with PRKAR1A gene mutation and Carney complex. Malignant behavior has been reported in a significant number of patients.

Also known as melanocytic neurilemmoma, melanocytic schwannoma, melanotic neurinoma, melanotic schwannoma, melanotic schwannoma (morphologic abnormality), pigmented neurilemmoma, pigmented schwannoma — per MONDO

Also identified as

• DOID 3205 per MONDO
• ICD9 215.8 per MONDO
• NCIT C6970 per MONDO
• SCTID 404024000 per MONDO
• UMLS C1306247 per MONDO

Affected Organs