Skin pilomatrix carcinoma

Skin pilomatrix carcinoma

Definition

A very rare, locally aggressive, malignant neoplasm of the hair follicle. The majority of the cases arise de novo, however malignant transformation from a pre-existing pilomatricoma has been reported. It usually presents as a solitary nodule in the head and neck, upper extremities, or buttocks. Morphologically, it is characterized by the presence of aggregates of basaloid cells infiltrating the dermis. Masses of ghost cells are present in the cellular aggregates. Complete surgical excision is the treatment of choice. If it is not completely removed, it usually recurs, but it rarely metastasizes to distant anatomic sites.

Also known as calcified epithelial carcinoma of Malherbe, calcifying epitheliocarcinoma, invasive pilomatrixoma, malignant pilomatricoma, matrical carcinoma, Pilomatrical carcinoma, pilomatrix carcinoma, pilomatrix carcinoma of skin, pilomatrix carcinoma of the skin, pilomatrix skin carcinoma, Trichomatrical carcinoma — per MONDO

Also identified as

Affected Organs

Organ Involvement Source
Exocrine system Disease Has Primary Anatomic Site NCIT · CC BY 4.0
Hair Disease Has Primary Anatomic Site NCIT · CC BY 4.0
Hair follicles Disease Has Primary Anatomic Site NCIT · CC BY 4.0
Integumental system Disease Has Associated Anatomic Site NCIT · CC BY 4.0
Skin of body Disease Has Associated Anatomic Site NCIT · CC BY 4.0
Skin of body Disease Has Primary Anatomic Site NCIT · CC BY 4.0