Chronic lymphoproliferative disorder of NK-cells

Definition

An Epstein-Barr virus negative disorder with a chronic clinical course affecting predominantly adults and characterized by the proliferation of large granular lymphocytes with natural killer cell immunophenotype. The T-cell receptor genes are not rearranged.

Also known as chronic lymphoproliferative disorder of NK-cells, chronic NK lymphocytosis, chronic NK-cell lymphocytosis, chronic NK-large granular lymphocyte lymphoproliferative disorder, chronic NK-LGL lymphoproliferative disorder, CLPD-NK, CNKL, indolent large granular NK-cell lymphoproliferative disorder, indolent NK-cell lymphoproliferative disorder, natural killer-cell large granular lymphocyte leukaemia, natural killer-cell large granular lymphocyte leukemia, NK-cell large granular lymphocyte lymphocytosis, NK-cell lineage granular lymphocyte proliferative disorder, NK-LGL leukaemia, NK-LGL leukemia, NK-LGLL, NK-type lymphoproliferative disorder of granular lymphocytes — per MONDO

Also identified as

• DOID 7465 per MONDO
• NCIT C39591 per MONDO
• Orphanet 512017 per MONDO
• SCTID 722955006 per MONDO
• UMLS C1512709 per MONDO

Affected Organs