Osteosclerotic plasma cell myeloma
Osteosclerotic plasma cell myeloma
Definition
A plasma cell neoplasm associated with osteosclerotic and fibrotic changes in the bone trabeculae. Often, the lymph nodes show changes resembling the plasma cell variant of Castleman disease. It is often part of POEMS syndrome which is characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes.
Also known as osteosclerotic multiple myeloma, osteosclerotic plasma cell myeloma — per MONDO
Also identified as
Affected Organs
| Organ | Involvement | Source |
|---|---|---|
| Hematopoietic system | Disease Has Associated Anatomic Site | NCIT · CC BY 4.0 |
| Lymphoid system | Disease Has Primary Anatomic Site | NCIT · CC BY 4.0 |