Neoplasm of mature B-cells

Definition

A neoplasm of follicle center B cells which has at least a partial follicular pattern. Follicular lymphomas comprise about 35% of adult non-Hodgkin lymphomas in the U.S. and 22% worldwide. Most patients have widespread disease at diagnosis. Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present. The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)]. Histological grade correlates with prognosis. Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001).

Also known as mature B-cell lymphocytic neoplasm, mature B-cell neoplasm — per MONDO

Also identified as

• DOID 706 per MONDO
• ICD9 202.0 per MONDO
• NCIT C27910 per MONDO
• SCTID 269476000 per MONDO
• UMLS C1334633 per MONDO

Affected Organs