Large cell neuroendocrine carcinoma
Large cell neuroendocrine carcinoma
Definition
A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas.
Also known as large cell NEC, large cell neuroendocrine carcinoma, large-cell neuroendocrine carcinoma, LCNEC — per MONDO
Also identified as
Affected Organs
| Organ | Involvement | Source |
|---|---|---|
| Endocrine gland | Disease Has Associated Anatomic Site | NCIT · CC BY 4.0 |
| Endocrine gland | Disease Has Primary Anatomic Site | NCIT · CC BY 4.0 |