Human African trypanosomiasis

Definition

A parasitic disorder caused by protozoa of the Trypanosoma brucei species. It is transmitted by flies and is endemic in various regions of Sub-Saharan Africa. Signs and symptoms include fever, joint pain, headache, and significant swelling of the lymph nodes. If left untreated, the parasitic infection causes anemia, heart, kidney, and endocrine failure, and neurologic damage. Subsequently patients develop confusion, disruption of the sleep cycle, and mental deterioration. The infection may lead to coma and death.

Also known as Africam sleeping sickness, African trypanosomiasis, sleeping sickness — per MONDO

Also identified as

• DOID 10112 per MONDO
• ICD9 086.5 per MONDO
• MESH D014353 per MONDO
• NCIT C84541 per MONDO
• Orphanet 3385 per MONDO
• SCTID 27031003 per MONDO
• UMLS C0041228 per MONDO

Drugs indicated