Granular cell tumor

Definition

An unusual benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. It was originally thought to be a tumor originating from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells. It affects females more often than males and it usually presents as a solitary mass. A minority of patients have multiple tumors. It can arise from many anatomic sites including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast.

Also known as Abrikossoff tumor, Abrikossoff tumour, Abrikossoff's tumor, Abrikossoff's tumour, granular cell myoblastoma, granular cell neoplasm, granular cell nerve sheath tumor, granular cell nerve sheath tumour, granular cell schwannoma, granular cell tumor, granular cell tumor (morphologic abnormality), granular cell tumour (morphologic abnormality) — per MONDO

Also identified as

• DOID 2411 per MONDO
• ICD9 215.9 per MONDO
• MESH C535558 per MONDO
• MESH D016586 per MONDO
• NCIT C3474 per MONDO
• SCTID 404035005 per MONDO
• UMLS C0085167 per MONDO

Affected Organs