Renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions
Renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions
Definition
A group of kidney carcinomas characterized by the presence of different translocations involving the chromosome Xp11.2. These translocations result in the creation of gene fusions involving the TFE3 gene. Patients are usually children and young adults. Morphologically, the malignant epithelial cells form papillary patterns.
Also known as renal cell cancer associated with Xp11.2 translocations/TFE3 Gene fusions, renal cell carcinoma associated with Xp11.2 translocations/TFE3 gene fusions, TFE3-Rearranged renal cell carcinoma, tRCC, Xp11.2 translocation-related renal cell carcinoma — per MONDO
Also identified as
Affected Organs
| Organ | Involvement | Source |
|---|---|---|
| Adult mammalian kidney | Disease Has Associated Anatomic Site | NCIT · CC BY 4.0 |
| Adult mammalian kidney | Disease Has Primary Anatomic Site | NCIT · CC BY 4.0 |
| Genitourinary system | Disease Has Associated Anatomic Site | NCIT · CC BY 4.0 |
| Genitourinary system | Disease Has Primary Anatomic Site | NCIT · CC BY 4.0 |
| Nephron tubule | Disease Has Primary Anatomic Site | NCIT · CC BY 4.0 |
| Renal system | Disease Has Associated Anatomic Site | NCIT · CC BY 4.0 |
| Renal system | Disease Has Primary Anatomic Site | NCIT · CC BY 4.0 |
| Upper urinary tract | Disease Has Associated Anatomic Site | NCIT · CC BY 4.0 |