Inflammatory breast carcinoma

Definition

An advanced, invasive breast adenocarcinoma characterized by the presence of distinct changes in the overlying skin. These changes include diffuse erythema, edema, peau d'orange (skin of an orange) appearance, tenderness, induration, warmth, enlargement, and in some cases a palpable mass. The skin changes are the consequence of lymphatic obstruction from the underlying invasive breast adenocarcinoma. Microscopically, the dermal lymphatics show prominent infiltration by malignant cells. The invasive breast adenocarcinoma is usually of ductal, NOS type. There is not significant inflammatory cell infiltrate present, despite the name of this carcinoma.

Also known as inflammatory breast cancer, inflammatory breast carcinoma, inflammatory carcinoma of breast, inflammatory carcinoma of the breast, mastitis Carcinomatosa — per MONDO

Also identified as

• DOID 6263 per MONDO
• MESH D058922 per MONDO
• NCIT C4001 per MONDO
• Orphanet 694963 per MONDO
• SCTID 254840009 per MONDO
• UMLS C0278601 per MONDO

Affected Organs