Gerstmann-Straussler-Scheinker syndrome

ICD-10 Code A81.82

Gerstmann-Straussler-Scheinker syndrome

Definition

A very rare and fatal disorder of spongiform encephalopathy usually caused by mutations of the prion protein (PRNP) gene. It is characterized by the accumulation of amyloid in the brain. Signs and symptoms include lack of motor coordination, unsteady gait, and difficulty walking. As the disease progresses, patients develop speech difficulties and dementia.

Also known as Gerstmann-Straussler-Scheinker disease, prion dementia, subacute spongiform encephalopathy, Gerstmann-Straussler type — per MONDO

Also identified as

Affected Organs

Organ Involvement Source
Brain Disease Has Associated Anatomic Site NCIT · CC BY 4.0
Brain Disease Has Primary Anatomic Site NCIT · CC BY 4.0
Central nervous system Disease Has Associated Anatomic Site NCIT · CC BY 4.0
Central nervous system Disease Has Primary Anatomic Site NCIT · CC BY 4.0
Nervous system Disease Has Associated Anatomic Site NCIT · CC BY 4.0
Nervous system Disease Has Primary Anatomic Site NCIT · CC BY 4.0