Acute monocytic leukemia

Definition

Acute monoblastic leukemia (AML-M5), is one of the most common subtypes of acute myeloid leukemia (AML) that is either comprised of more than 80% of monoblasts (AML-M5a) or 30-80% monoblasts with (pro)monocytic differentiation (AML-M5b). AML-M5 presents with asthenia, pallor, fever, and dizziness. Specific features of AML-M5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed in AML-M5 is t(9;11).

Also known as acute monoblastic leukaemia and acute monocytic leukaemia, acute monocytic leukaemia (FAB M5B), acute monocytic leukemia, acute monocytic leukemia (FAB M5B), acute monocytic leukemia, morphology (morphologic abnormality), AML M5, leukemia, monocytic, malignant, monocytic leukemia, acute — per MONDO

Also identified as

• DOID 8864 per MONDO
• ICD10CM C93.0 per MONDO
• ICD9 206.0 per MONDO
• MESH D007948 per MONDO
• NCIT C4861 per MONDO
• OMIM 151380 per MONDO
• Orphanet 514 per MONDO
• SCTID 413441006 per MONDO
• UMLS C0023465 per MONDO

Affected Organs