Transient myeloproliferative syndrome

Definition

A myeloid proliferation occurring in newborns with Down syndrome. It is clinically and morphologically indistinguishable from acute myeloid leukemia and is associated with GATA1 mutations. The blasts display morphologic and immunophenotypic features of megakaryocytic lineage. In the majority of patients the myeloid proliferation undergoes spontaneous remission.

Also known as leukemia, transient, of Down syndrome, MST, TAM, TMD, transient abnormal myelopoiesis, Transient abnormal myelopoiesis associated with Down syndrome, transient leukaemia, transient leurkemia of Down syndrome, transient myeloproliferative disease, transient myeloproliferative disorder, transient myeloproliferative syndrome, transient myeloproliferative syndrome (disease) — per MONDO

Also identified as

• DOID 0060888 per MONDO
• MESH C563551 per MONDO
• NCIT C82339 per MONDO
• OMIM 159595 per MONDO
• Orphanet 420611 per MONDO
• SCTID 721307000 per MONDO
• UMLS C1834582 per MONDO

Affected Organs