Multiple endocrine neoplasia type 2B

Multiple endocrine neoplasia type 2B

Definition

An autosomal dominant disorder caused by specific pathogenic variants in the RET gene, characterized by an increased risk of very early onset medullary thyroid carcinoma, pheochromocytoma, and hyperparathyroidism, and mucosal neuromas.

Also known as men 2B, men IIB, men type 2B, men type IIB, MEN2B, multiple endocrine adenomatosis type IIB, multiple endocrine neoplasia IIB, multiple endocrine neoplasia type 2B, multiple endocrine neoplasia type 3, multiple endocrine neoplasia type IIB, multiple endocrine neoplasia type III, multiple endocrine neoplasia, type III, RET-related multiple endocrine neoplasia type 2B, Wagenmann-Froboese syndrome — per MONDO

Also identified as

Affected Organs

Organ Involvement Source
Endocrine gland Disease Has Associated Anatomic Site NCIT · CC BY 4.0
Endocrine gland Disease Has Primary Anatomic Site NCIT · CC BY 4.0