Cerebellar ataxia-hypogonadism syndrome
Cerebellar ataxia-hypogonadism syndrome
Definition
Cerebellar ataxia-hypogonadism syndrome is a very rare autosomal recessive neurodegenerative disorder characterized by the combination of progressive cerebellar ataxia with onset from early childhood to the fourth decade, and hypogonadotropic hypogonadism (delayed puberty and lack of secondary sex characteristics). Cerebellar ataxia-hypogonadism syndrome belongs to a clinical continuum of neurodegenerative disorders along with clinically overlapping disorders such as ataxia-hypogonadism-choroidal dystrophy syndrome.
Also known as Gordon-Holmes syndrome, luteinizing hormone-releasing hormone deficiency with ataxia — per MONDO