Spermatogenic failure 5
Spermatogenic failure 5
Definition
A male infertility due to sperm disorder characterized by the presence, in sperm, of a very high percentage of spermatozoa with enlarged head, irregular head shape, multiple flagella, and abnormal midpiece and acrosome. It is generally associated with severe oligoasthenozoospermia and a high rate of sperm chromosomal abnormalities (polyploidy, aneuploidy).
Also known as macrocephalic sperm head syndrome, macrozoospermia with multiflagellar polyploid spermatozoa, male infertility due to large-headed multiflagellar polyploid spermatozoa, male infertility due to macrozoospermia, male infertility with large-headed, multiflagellar, polyploid spermatozoa, spermatogenic failure 5, spermatogenic failure type 5, SPGF5 — per MONDO