Laryngo-onycho-cutaneous syndrome
Laryngo-onycho-cutaneous syndrome
Definition
LOC syndrome is a subtype of junctional epidermolysis bullosa (JEB) characterized by an altered cry in the neonatal period and by aberrant production of granulation tissue in particular affecting the upper airway tract, conjunctiva and periungual/subungual sites.
Also known as laryngeal and ocular granulation tissue in children from the Indian subcontinent syndrome, laryngo-onycho-cutaneous syndrome, LOC syndrome, logic syndrome, Shabbir syndrome — per MONDO