Mal de Meleda
Mal de Meleda
Definition
Mal de Melada (MdM) is a diffuse palmoplantar keratoderma initially reported from of the Island of Meleda characterized by symmetric palmoplantar hyperkeratosis that progressively extends to the dorsal surfaces of hands and feet (transgradiens). The disease can be associated to hyperhidrosis, lichenoid plaques and perioral erythema.
Also known as keratosis palmoplantaris transgrediens of Siemens, mal de Meleda, Meleda Disease — per MONDO