Multicentric osteolysis, nodulosis, and arthropathy
Multicentric osteolysis, nodulosis, and arthropathy
Definition
A rare, autosomal recessive inherited syndrome caused by mutations in the MMP2 gene. It is characterized by the presence of multiple, painless subcutaneous nodules, osteolysis particularly in the hands and feet, osteoporosis, and arthropathy.
Also known as Al-Aqeel Sewairi syndrome, MONA, MONA, MMP2-related, multicentric osteolysis, nodulosis and arthropathy, MMP2-related, multicentric osteolysis, nodulosis, and arthropathy, NAO syndrome, nodulosis-arthropathy-osteolysis syndrome, osteolysis, hereditary multicentric, Torg syndrome, Winchester-Torg syndrome — per MONDO