Gastrointestinal stromal tumor

Definition

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal (GI) tract, typically presenting in adults over the age of 40 (mean age 63), and only rarely in children, in various regions of the GI tract, most commonly the stomach or small intestine but also less commonly in the esophagus, appendix, rectum and colon. GISTs can be asymptomatic or present with various non-specific signs, depending on the location and size of tumor, such as loss of appetite, anemia, weight loss, fatigue, abdominal discomfort or fullness, nausea, vomiting, as well as an abdominal mass, blood in stool, and intestinal obstruction. GISTs can also be seen in familial syndromes such as Carney triad and neurofibromatosis type 1.

Also known as gastrointestinal stromal neoplasm, gastrointestinal stromal sarcoma, gastrointestinal stromal tumor, gastrointestinal stromal tumor (gist), gastrointestinal stromal tumor, familial, isolated cases, gastrointestinal stromal tumor, isolated cases, Gastrointestinal Stromal Tumors, gastrointestinal stromal tumour (gist), GIST — per MONDO

Also identified as

• DOID 9253 per MONDO
• ICD10CM C49.A per MONDO
• MESH D046152 per MONDO
• NCIT C3868 per MONDO
• OMIM 606764 per MONDO
• Orphanet 44890 per MONDO
• SCTID 420120006 per MONDO
• UMLS C0238198 per MONDO

Drugs indicated