Hereditary spastic paraplegia 37
Hereditary spastic paraplegia 37
Definition
Autosomal dominant spastic paraplegia type 37 is a pure form of hereditary spastic paraplegia characterized by a childhood- to adulthood-onset of slowly progressive spastic gait, extensor plantar responses, brisk tendon reflexes in arms and legs, decreased vibration sense at ankles and urinary dysfunction. Ankle clonus is also reported in some patients.
Also known as autosomal dominant spastic paraplegia type 37, hereditary spastic paraplegia type 37, SPG37 — per MONDO