Dopa-responsive dystonia due to sepiapterin reductase deficiency

Dopa-responsive dystonia due to sepiapterin reductase deficiency

Definition

Dopa responsive dystonia (DRD) due to sepiapterin reductase deficiency (SRD) is a very rare neurometabolic disorder characterized by dystonia with diurnal fluctuations, axial hypotonia, oculogyric crises, and delays in motor and cognitive development.

Also known as autosomal recessive sepiapterin reductase-deficient DRD, dopa-responsive dystonia due to sepiapterin reductase deficiency, DRD due to SRD, DYT-SPR, Sepiapterin Reductase Deficiency, SPR deficiency, SRD — per MONDO

Also identified as