Addison's disease

Definition

This condition is comnonly referred to as Addison disease or Addison's disease. It is also known as autoimmune adrenalitis. It is an acquired primary adrenal insufficiency. Addison disease results from the destruction of the bilateral adrenal cortex, leading to decreased adrenocortical hormones, including cortisol, aldosterone, and androgens. Addison disease's insidious course of action usually presents with glucocorticoid deficiency followed by mineralocorticoid. However, the condition can also present acutely, often triggered by intercurrent illness (MONDO:0019801 acute adrenal insufficiency also called Addisonian crisis). The presentation of adrenal insufficiency depends on the rate and extent of adrenal function involvement. The most common cause of primary adrenal insufficiency is Addison disease, associated with increased levels of 21-hydroxylase antibodies. PMID:28723023. Note the terms "Addison disease" and "Addison's disease" are ambiguous and sometimes are also used to refer to MONDO:0015128 'primary adrenal insufficieny' and MONDO:0015129 'chronic primary adrenal insufficiency'.

Also known as Addison disease, Addison's disease, autoimmune Addison disease, autoimmune Addison's disease, autoimmune adrenalitis, classic Addison's disease, primary Addison's disease — per MONDO

Also identified as

• NCIT C113814 per MONDO
• Orphanet 85138 per MONDO
• UMLS C0271737 per MONDO

Affected Organs