Congenital muscular dystrophy due to LMNA mutation
Congenital muscular dystrophy due to LMNA mutation
Definition
Congenital muscular dystrophy due to LMNA mutation is a rare congenital muscular dystrophy characterized by prominent axial hypotonia, dropped head syndrome, predominantly proximal muscle weakness in upper limbs/distal in lower limbs (with absent, poor or lost motor development), joint contractures (initially distal, later proximal), spine rigidity, and early respiratory insufficiency, in the presence of moderately elevated serum creatine kinase. Cardiac arrhythmias and sudden death have been also reported.
Also known as congenital muscular dystrophy caused by mutation in LMNA, L-CMD, LMNA congenital muscular dystrophy, LMNA-related congenital muscular dystrophy, muscular dystrophy Congenital, LMNA-related, muscular dystrophy, congenital — per MONDO
Also identified as
- DOID 0110640 per MONDO
- MESH C567708 per MONDO
- NCIT C148369 per MONDO
- OMIM 613205 per MONDO
- Orphanet 157973 per MONDO
- UMLS C2750785 per MONDO
Affected Organs
| Organ | Involvement | Source |
|---|---|---|
| Musculature | Disease Has Associated Anatomic Site | NCIT · CC BY 4.0 |
| Musculature | Disease Has Primary Anatomic Site | NCIT · CC BY 4.0 |
| Musculoskeletal system | Disease Has Associated Anatomic Site | NCIT · CC BY 4.0 |
| Musculoskeletal system | Disease Has Primary Anatomic Site | NCIT · CC BY 4.0 |
| Nervous system | Disease Has Associated Anatomic Site | NCIT · CC BY 4.0 |
| Nervous system | Disease Has Primary Anatomic Site | NCIT · CC BY 4.0 |
| Peripheral nervous system | Disease Has Associated Anatomic Site | NCIT · CC BY 4.0 |
| Peripheral nervous system | Disease Has Primary Anatomic Site | NCIT · CC BY 4.0 |