Isosorbide mononitrate
Isosorbide mononitrate
Definition
The mononitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide mononitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide mononitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05)
Also known as 1,4:3,6-Dianhydro-D-glucitol 5-nitrate, Imdur, ISMO, ISOSORBIDE MONONITRATE, Monoket, Monosordil — per NCIT
Also identified as
- ATC C01DA per NCIT
- NCIT NCIT:C47575 per NCIT
Indications
| Disease | Relation | Source |
|---|---|---|
| Gastroesophageal reflux disease | may treat | MEDRT · Public domain (U.S. Government work) |
| Heart failure | may treat | MEDRT · Public domain (U.S. Government work) |
| Poisoning | may treat | MEDRT · Public domain (U.S. Government work) |
Organ Effects
| Organ | Side effect / interaction | Source |
|---|---|---|
| Alimentary part of gastrointestinal system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Cardiovascular system | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Esophagus | may treat a disease of this organ | DERIVED · CC BY 4.0 |
| Heart | may treat a disease of this organ | DERIVED · CC BY 4.0 |
4 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.