Polidocanol

Definition

An alkyl polyglycol ether of lauryl alcohol with sclerosing and potential antineoplastic activities. Upon intralesional administration, polidocanol induces endothelial cell injury by disrupting calcium signaling and nitric oxide pathways. Following endothelial damage, platelets aggregate at the site of injury and attach to the venous wall, resulting in a dense network of platelets, cellular debris, and fibrin that occludes the vessel. Inducing endothelial cell damage within melanoma metastases may incite an antitumor response in untreated bystander lesions and inhibit the growth of in transit metastases and other cutaneous lesions.

Also known as Aethoxysklerol, Asclera, Dodecylnonaoxyethylene Glycol Monoether, Laureth 9, Laureth-9, Lauromacrogol 400, Nonaethylene Glycol Monododecyl Ether, POLIDOCANOL — per NCIT

Also identified as

• ATC C05BB02 per RXNORM
• NCIT NCIT:C158511 per NCIT
• SCTID 427905004 per RXNORM
• SCTID 427906003 per RXNORM
• UNII 0AWH8BFG9A per RXNORM

Indications