Cabazitaxel

Definition

A semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB).

Also known as 1-hydroxy-7beta,10beta-dimethoxy-9-oxo-5beta,20-epoxytax-11-ene-2alpha,4,13alpha-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-{[(tertbutoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoate], CABAZITAXEL, Jevtana, RPR 116258A, RPR-116258A, RPR116258A, Taxoid XRP6258, TXD 258, TXD-258, TXD258, XRP 6258, XRP-6258, XRP6258 — per NCIT

Also identified as

• ATC L01CD04 per RXNORM
• NCIT NCIT:C66937 per NCIT
• SCTID 446706007 per RXNORM
• SCTID 447182009 per RXNORM
• UNII 51F690397J per RXNORM

Indications