Sipuleucel-T

Definition

A cell-based vaccine composed of autologous antigen-presenting peripheral blood mononuclear cells (enriched for a dendritic cell fraction) that have been exposed to a recombinant protein consisting of granulocyte-macrophage colony-stimulating factor (GM-CSF) fused to prostatic-acid phosphatase (PAP), a protein expressed by prostate cancer cells. Upon administration, the vaccine may stimulate an antitumor T-cell response against tumor cells expressing PAP. (NCI05)

Also known as APC 8015, APC-8015, APC8015, APC8015 Vaccine, PA2024 (PAP/GM-CSF)-Loaded Dendritic Cell Vaccine, Provenge, SipT, SIPULEUCEL-T — per NCIT

Also identified as

• ATC L03AX17 per RXNORM
• NCIT NCIT:C1985 per NCIT
• UNII 8Q622VDR18 per RXNORM

Indications