Diltiazem

ATC Code C08DB01

Diltiazem

Definition

A benzothiazepine derivative with anti-hypertensive, antiarrhythmic properties. Diltiazem blocks voltage-sensitive calcium channels in the blood vessels, by inhibiting the ion-control gating mechanisms, thereby preventing calcium levels increase by other revenues. Alternatively, it has been suggested that this agent also interferes with the release of calcium from the sarcoplasmic reticulum and inhibits the influx of extracellular calcium across both the myocardial and vascular smooth muscle cell membranes. The overall low calcium levels leads to dilatation of the main coronary and systemic arteries and decreasing myocardial contractility, decreased peripheral arterial resistance, improved oxygen delivery to the myocardial tissue, and decreased cardiac output.

Also known as DILTIAZEM — per NCIT

Also identified as

Indications

Disease Relation Source
Atrial fibrillation may treat MEDRT · Public domain (U.S. Government work)
Atrial flutter may treat MEDRT · Public domain (U.S. Government work)
Hypertensive disorder may treat MEDRT · Public domain (U.S. Government work)
Myocardial infarction may treat MEDRT · Public domain (U.S. Government work)
Prinzmetal angina may treat MEDRT · Public domain (U.S. Government work)

Organ Effects

Organ Side effect / interaction Source
Cardiovascular system may treat a disease of this organ DERIVED · CC BY 4.0
Heart may treat a disease of this organ DERIVED · CC BY 4.0
Musculature may treat a disease of this organ DERIVED · CC BY 4.0
Musculoskeletal system may treat a disease of this organ DERIVED · CC BY 4.0
Myocardium may treat a disease of this organ DERIVED · CC BY 4.0

5 entries above are marked DERIVED: Atlas Médico inferred them by combining two sourced claims, and no source asserts these links directly. Treat them as a navigation aid, not as a clinical statement.